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Verdens helseorganisasjons smertetrapp for kreftrelaterte smerter gjelder smerter som skyldes kreftsykdom og ikke andre smerterGuy starter oftest den smertestillende behandling med et svagt virkende middel, hvis ikke smerterne allerede er blevet stærke.Langvarig bruk av opioider har tradisjonelt stort sett blitt brukt for å dempe sterke smerter